Does NMN Raise Blood Pressure? What the Evidence Shows

NMN is one of the most popular anti-aging supplements in the world. But a lot of people worry it might raise their blood pressure. Here's what the actual research says — not the hype.

📋 Simple Summary

NMN (nicotinamide mononucleotide) is a supplement that boosts a molecule your cells need for energy, called NAD+. Some people worry NMN might raise blood pressure. The evidence says the opposite.

A 2026 analysis that combined 10 human trials found NMN slightly lowered the bottom number of blood pressure (diastolic). In people over 60, it also lowered the top number (systolic). No good study found that NMN raises blood pressure.

The effect is small — a few points on the blood pressure scale — and the trials are short. So more research is needed. But the "NMN raises blood pressure" worry isn't supported by the data.

The detailed breakdown continues below for those who want the full science.

Evidence Tier: 🥈 Silver — a meta-analysis of randomized controlled trials (the gold-standard study design), but with a small total sample and short durations; the authors call their own findings "preliminary and suggestive."

Category Tags: 💊 Supplements & Compounds, 🧬 The Fundamentals

What You Need to Know

The short answer: NMN does not appear to raise blood pressure. If anything, it may lower it slightly.

Why do people ask this? NMN is a form of vitamin B3, and high doses of one specific B3 form — niacin (nicotinic acid) — can cause a warm skin flush and, in some cases, affect blood pressure. NMN is a different compound, much further along the body's chemical pathway, and it doesn't cause the niacin flush. The confusion is understandable, but the two are not the same thing.

Key Findings

Diastolic blood pressure fell slightly. A 2026 meta-analysis of 10 randomized controlled trials (349 people) found NMN lowered resting diastolic blood pressure — the bottom number — by about 2.15 mmHg on average (95% CI −3.68 to −0.61).
Older adults saw a bigger benefit. In people aged 60 and older, NMN lowered systolic blood pressure — the top number — by about 3.94 mmHg (95% CI −7.06 to −0.82).
No study found NMN raised blood pressure. The researchers searched the literature specifically for this and found zero evidence of an increase.
A second, independent review agrees. A 2026 safety review of 15 trials (doses 250–2,000 mg/day, lasting up to 24 weeks) found no significant change in systolic blood pressure, and a slight decrease in diastolic.
One trial saw a notably larger drop. A 2023 trial of 30 overweight adults given a microcrystalline form of NMN (MIB-626) for 28 days saw diastolic blood pressure fall by about 7 mmHg more than placebo (P = .034).
There's a biological reason for all of this. People with high blood pressure tend to have low NAD+ levels, and restoring NAD+ (which is exactly what NMN does) appears to help blood vessels relax and function better.

Our Take

We are researchers, not doctors. The evidence suggests NMN does not raise blood pressure — and may lower it slightly, especially in older adults. The effect is modest and the trials are short-term, so we can't call it a treatment for high blood pressure. If you're taking NMN, keep an eye on your own numbers; if you already have high or low blood pressure, or take blood-pressure medication, talk to your doctor before adding anything new.

❓ Common Questions

Does NMN raise blood pressure?

No. The best evidence points the opposite way. A 2026 meta-analysis of 10 randomized trials found NMN slightly lowered diastolic blood pressure (about 2 mmHg) and, in adults 60 and older, lowered systolic blood pressure by about 4 mmHg. No quality study found that NMN raises blood pressure.

What is NMN and how does it work?

NMN (nicotinamide mononucleotide) is a form of vitamin B3 that the body converts into NAD+ (nicotinamide adenine dinucleotide) — a molecule every cell needs for energy and repair. NAD+ levels fall as we age, and low NAD+ is linked to stiffer blood vessels and higher blood pressure. By restoring NAD+, NMN may help blood vessels stay flexible.

What does the evidence actually show about NMN and blood pressure?

A 2026 meta-analysis of 10 randomized controlled trials (349 people) found NMN lowered resting diastolic blood pressure by about 2.15 mmHg on average, and lowered systolic blood pressure by about 3.94 mmHg in people aged 60 and older. The authors describe these as preliminary and suggestive findings, because the trials are small and short-term. Longer, larger trials are needed to confirm.

Could NMN lower blood pressure too much?

The observed effects are small — a few mmHg — so they're unlikely to cause problems in healthy people. But if you have low blood pressure, or take blood-pressure medication, talk to your doctor before adding NMN. The combination could matter, even if the effect of NMN alone is mild.

Is NMN safe overall?

Short-term, yes. A separate 2026 safety review of 15 trials (doses 250 to 2,000 mg per day, lasting up to 24 weeks) found no increase in side effects, no significant change in liver enzymes, and no significant change in systolic blood pressure. What we don't have yet is long-term safety data beyond a few months.

Sources

Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2026. PMID: 41901064.
Safety and Metabolism-Related Outcomes of Oral Nicotinamide Mononucleotide Supplementation in Adults: A Systematic Review and Meta-Analysis. Nutrients. 2026. PMID: 42514320.
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study. The Journal of Clinical Endocrinology & Metabolism. 2023. PMID: 36740954.
CD38-mediated endothelial NAD+ depletion drives hypertension. Signal Transduction and Targeted Therapy. 2023. PMID: 37718359.
Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals. Cureus. 2022. PMID: 36225528.

⚠️ We are researchers, not doctors. Nothing here is medical advice. Talk to your doctor before starting any supplement or changing your health routine.